![]() ![]() Blattner retired from the university in July, 2011, but remains active at the helm of two companies he founded. Other interests include bioinformatics, technology development, and genetic engineering/re-engineering of bacterial genomes. It turns out that many virulence determinants of the different pathogens are similar, allowing identification of a “pathosphere” of virulence genes that make up the pathogenic potential of these bacteria. They also sequenced Yersinia pestis (plague), Shigella flexneri (dysentary), and Salmonella Typhi (typhoid fever). coli and a strain causing neonatal sepsis and meningitis. coli, followed by a uropathogenic strain of E. The first strain selected for comparison was the infamous O157:H7 “hamburger strain” of E. Interested in hypothesis-driven comparative and evolutionary genomics, the lab sequenced the genomes of several pathogens related to E. coli through DNA chip analysis of global gene expression, and by phenotypic analysis of conditional knock-out mutations. ![]() After accomplishing that, sequencing the genome of Escherichia coli K-12, his lab turned to large scale functional genomics of E. ![]() One of the early leaders of the genomics revolution, Fred Blattner was the first to propose sequencing the entire genome of an organism. Genomics, gene regulation, bacteria, bioinformatics, DNA chips, genome engineering
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